Group of Prof. Tinnefeld - Faculty for Chemistry and Pharmacy

The Tinnefeld Group - Physical Chemistry & Nanobiosciences

Welcome to the Tinnefeld lab!

With our background in single-molecule detection and superresolution microscopy, we develop new methods and molecular tools to study biomolecular processes, structures and dynamics. It is our ultimate vision to use fluorescence for recording movies of the molecular processes that are the basis of life.

With the progress of using DNA as a nanomaterial (DNA nanotechnology), we also got excited about building modular molecular devices with a variety of functions including molecular signal amplifiers, force sensors, and nanorulers. Such devices are the basis of a fundamental new approach to biosensing and molecular robotics.

Our NanoBioSciences group brings together unique interdisciplinarity creating synergy from molecular biology, physical chemistry, biophysics and nanophotonics.

       

                                                                         News

14.12.2021

Andrés M. Vera's and Merve-Zeynep Kesici's article "A simple and general approach to control the activity of DNA processing enzymes" is now online in Nucleic Acids Research. This new approach is also featured in the LMU newsroom. Kudos to the team!

26.11.2021

The Tinnefeld group won amongst others the CeNS Publication Award 2021 in the category "Scientific Breakthrough" for their publication on NACHOS in Nature Communications. Check out the announcement and the paper. Congratulations to all the winners!
                                         

17.11.2021

Andrés M. Vera's preprint on light-activated DNA-processing enzymes is now online in BioRxiv. Also check out the editorial in "Laborjournal" here!

Nov 2021

The Römer-Prize was awarded to Patrick Schüler for his Master thesis and to Dr. Viktorija Glembockyté in the postdoc category for outstanding achievements. Check out the news.

Congratulations!                                         

01.10.2021

26th International Workshop on “Single Molecule Spectroscopy and Super-resolution Microscopy” (September 29 – October 1, 2021, Berlin, Germany): "Best talk by a young researcher" awarded to  Jonas Zähringer for his presentation on "Exploiting Fluorescence Lifetime in Pulsed Interleaved MINFLUX". Check it out here!

01.10.2021

Today Prof. Dr. Philip Tinnefeld takes over the office from Prof. Dr. Angelika Vollmar as the dean of the faculty of chemistry and pharmacy. We are confident that he will move our faculty forward in new and exciting ways and wish him lots of success in his new role!

10.06.2021

'Graphene unlocks its potential for superresolution microscopy'

Scientists from LMU have unlocked the full potential of graphene for fluorescence microscopy. The study shows a microscopy resolution world record of 3 nanometer. This might turn graphene into the new standard platform for state-of-the art microscopy. More.

© Vera Hiendl / e-conversion

12-15.04.2021 18th Annual Conference on Foundations of Nanoscience (FNANO 2021, April 12-15, 2021, online): "Excellent poster presentation by a student or postdoc" awarded to Michael Scheckenbach and Renukka Yaadav.
 

Publications 2021

Martina Pfeiffer, Kateryna Trofymchuk, Simona Ranallo, Francesco Ricci, Florian Steiner, Fiona Cole, Viktorija Glembockyte, Philip Tinnefeld: Single antibody detection in a DNA origami nanoantenna, Iscience. DOI: 10.1016/j.isci.2021.103072

Viktorija Glembockyte, Lennart Grabenhorst, Kateryna Trofymchuk, Philip Tinnefeld: DNA Origami Nanoantennas for Fluorescence Enhancement, Accounts of Chemical Research. DOI: 10.1021/acs.accounts.1c00307

Andrés Manuel Vera, Albert Galera-Prat, Michał Wojciechowski, Bartosz Różycki, Douglas V Laurents, Mariano Carrión-Vázquez, Marek Cieplak, Philip Tinnefeld: Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization, Structure. DOI: 10.1016/j.str.2021.01.006

I. Kamińska *, J. Bohlen, R. Yaadav, P. Schüler, M. Raab, T. Schröder, J. Zähringer, K. Zielonka, S. Krause, P. Tinnefeld *: Graphene Energy Transfer for Single-Molecule Biophysics , Biosensing & Superresolution Microscopy , Adv. Mater. , DOI: 10.1002 / adma.202101099

K. Hübner, H. Joshi, A. Aksimentiev, F. Stefani, P. Tinnefeld, G. Acuna: Determining the In-Plane Orientation and Binding Mode of Single Fluorescent Dyes in DNA Origami Structures , ACS Nano , 15 (3), 5109-5117.

S. Krause, E. Ploetz, J. Bohlen, P. Schüler, R. Yaadav, F. Selbach, F. Steiner, I. Kamińska, P. Tinnefeld: Graphene-on-Glass Preparation and Cleaning Methods Characterized by Single-Molecule DNA Origami Fluorescent Probes and Raman SpectroscopyACS Nano  15 (4), 6430-6438.

AM Szalai, B. Siarry, J. Lukin, S. Giusti, N. Unsain, A. Cáceres, F. Steiner, P. Tinnefeld, D. Refojo, TM Jovin, FD Stefani: Super-resolution Imaging of Energy Transfer by Intensity -Based STED-FRET , Nano Lett. 21, 2296-2303.

GJ Hedley, T. Schröder, F. Steiner, T. Eder, F. Hofmann, S. Bange, D. Laux, S. Höger, P. Tinnefeld, JM Lupton, J. Vogelsang: Picosecond time-resolved photon antibunching measures nanoscale exciton motion and the true number of chromophores , Nat. Commun. 12 (1327).

See Press Release LMU and e-conversion

AM Vera, A. Galera-Prat, M. Wojciechowski, B. Różycki, DV .Laurents, M. Carrión-Vázquez, M. Cieplak, P. Tinnefeld: Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization , Structure  29, 1-11.

M. Scheckenbach, T. Schubert, C. Forthmann, V. Glembockyte, P. Tinnefeld: Self-Regeneration and Self-Healing in DNA Origami Nanostructures , Angew.Chem. Int.Ed. 60,4931 - 4938.
Self  ‐ regeneration and selfhealing in DNA origami nanostructures, Angew. Chem. 2021, 133, 4982-4990.

See Press release e-conversion , Faculty of Chemistry and Pharmacy  and Chemistry Views

Cover Figure in  Angew.Chem. Int.Ed. 2021-60 / 9 and  Angew. Chem. 2021-133 / 9

K. Trofymchuk, V. Glembockyte, L. Grabenhorst, F. Steiner, C. Vietz, C. Close, M. Pfeiffer, L. Richter, ML Schütte, F. Selbach, R. Yaadav, J. Zähringer, Q. Wei , A. Ozcan, B. Lalkens, GP Acuna, P. Tinnefeld: Addressable nanoantennas with cleared hotspots for single-molecule detection on a portable smartphone microscope , Nat. Commun. 12 (950)

See Press Release LMU

L. Shani, P. Tinnefeld, Y. Fleger, A. Sharoni, BY Shapiro, A. Shaulov, O. Gang, Y. Yeshurun: DNA origami based superconducting nanowires , AIP Advances 11 (1)

See Press release Phys.Org.

LA Masullo, F. Steiner, J. Zähringer, LF Lopez, J. Bohlen, L. Richter, F. Cole, P. Tinnefeld *, FD Stefani *: Pulsed-Interleaved MINFLUX , Nano Lett.  21 (1), 840-846.

See Press release nanowerk  and LMU

2020 Martina Pfeiffer was awarded with the Römer-Preis for her Master Thesis
2020-2024 Prof. Philip Tinnefeld is an Editorial Advisory Board Member of Analysis & Sensing

27./28.11.2019

" Diagnostics-4-Future Conference 2019 ", Konstanz: Poster Award for Sarah Ochmann (1st place) and Lennart Grabenhorst (2nd place)

(see  https://www.biolago.org/2019/12/12/die-zukunft-der-diagnostik-digital-und-naeher-am-patienten/ )

05.11.2019

Dr. Carolin Vietz (AK Tinnefeld) was awarded with the Heinrich Büssing Prize  by the Braunschweigischer Hochschulbund eV for her outstanding dissertation

(see https://magazin.tu-braunschweig.de/pi-post/nanonantennen-mobile-marketing-und-roboterbalance /

03-06.09.2019

Annual workshop on "Single Molecule Spectroscopy and Ultra Sensitive Analysis in the Life Sciences (03.-06.09.2019, Berlin): PicoQuant StudentAward for Tim Schröder, Tinnefeld-group (see  https://www.picoquant.com/scientific/award -single-molecule-workshop )

03-05.04.2019

Single-Molecule Sensors and NanoSystems International Conference (S3IC,  03.04.-05.04.2019, München): Poster Award for Dr. Viktorija Glembockyté and Dr. Florian Selbach, both Tinnefeld-group (see https://premc.org/conferences/s3ic2019/)

01.01.2019 - 31.12.2022 Prof. Philip Tinnefeld is Editorial Advisory Board Member of ChemPhysChem
30.11.2018

Prof. Philip Tinnefeld was elected to the board of the Center for NanoScience Munich (CeNS)

(see http://www.cens.de/news/news/news-single/article//election-of/)

April 2018

The EU-funded ChipScope Project Gets Leading Companies on Board

(see https://tinnefeld.cup.uni-muenchen.de/news/project-chipscope/)

24.11.2017

Prof. Philip Tinnefeld was (among others) awarded with the CeNS Publication Award 2017 for best interdisciplinary publication in Science 2016, 354(6310), 305-307.

(see https://www.cens.de/research/cens-publication-award/cens-award-2017/)

03.11.2017

Prof. Philip Tinnefeld and others were awarded with the IHK Technology Transfer Prize 2017  by the Braunschweig Chamber of Commerce and Industry for their project "Spin-off with optical samples: Measuring the nanoworld"

(see  https://www.braunschweig.ihk.de/geschaeftsfelder/innovation-umwelt/technologietransferpreis/verleihung-2017.html )