Group of Prof. Tinnefeld - Faculty for Chemistry and Pharmacy

Dr. Andrés Vera Gómez

Dr. Andres Vera-Gomez
Department Chemie, LMU München
Butenandtstr. 5 - 13
81377 München

Büro 089/2180-77547 (Frau Steger)
Telefon 089/2180-77537
Raum-Nr. E1.003
Email Andres.Vera-Gomez"at"cup.lmu.de

I did my PhD in the Cajal Institute (Madrid, Spain), where I used AFM-based Single-Molecule Force Spectroscopy to study the mechanical properties of proteins and protein complexes (1.). Afterward, I was granted with a Marie Curie Individual Fellowship and move to Germany and join the lab of Professor Tinnefeld, where I learnt to master Single-Molecule FRET techniques (2.) and made myself familiar with the versatility of DNA-nanotechnology (3.).

Nowadays, I am the leader of the Single-Molecule biophysics subgroup in the Tinnefeld Lab, where I focus my energy on understanding the regulation and dynamics of multi-enzymatic bacterial protein complexes (4.,5.). Besides, I have recently developed a new technology to generate light-activated DNA and RNA polymerases on demand, which can be used for biotechnological applications and we are certain will revolutionize the qPCR and Hot start PCR field.

  1. A. M. Vera*, M. Carrión-Vázquez, Direct Identification of Protein–Protein Interactions by Single-Molecule Force Spectroscopy. Angewandte Chemie International Edition 55, 13970-13973 (2016).
  2. B. Hellenkamp et al., Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study. Nature Methods 15, 669-676 (2018).
  3. K. Kramm et al., DNA origami-based single-molecule force spectroscopy unravels the molecular basis of RNA Polymerase III pre-initiation complex stability. 775528 (2019).
  4. Z. Liu et al., High Force Catch Bond Mechanism of Bacterial Adhesion in the Human Gut. 2020.2001.2021.913590 (2020).
  5. A. M. Vera* et al., smFRET Detects Dual Binding Modes Modulated by Proline Isomerization in a Mega-Dalton Multi-Enzyme Complex. 2019.2012.2019.882373 (2019).

*corresponding author