Dr. Andrés Vera Gómez

Office089/2180-77547 (Frau Steger)
Telefon089/2180-77537
RoomE1.003
E-mailAndres.Vera-Gomez”at”cup.lmu.de
Project subgroup

I did my PhD in the Cajal Institute (Madrid, Spain), where I used AFM-based Single-Molecule Force Spectroscopy to study the mechanical properties of proteins and protein complexes (1.). Afterward, I was granted with a Marie Curie Individual Fellowship and move to Germany and join the lab of Professor Tinnefeld, where I learnt to master Single-Molecule FRET techniques (2.) and made myself familiar with the versatility of DNA-nanotechnology (3.).

Nowadays, I am the leader of the Single-Molecule biophysics subgroup in the Tinnefeld Lab, where I focus my energy on understanding the regulation and dynamics of multi-enzymatic bacterial protein complexes (4.,5.). Besides, I have recently developed a new technology to generate light-activated DNA and RNA polymerases on demand, which can be used for biotechnological applications and we are certain will revolutionize the qPCR and Hot start PCR field.

Publications

A simple and general approach to generate photoactivatable DNA processing enzymes

Merve-Zeynep Kesici; Philip Tinnefeld; Andrés Manuel Vera

A simple and general approach to generate photoactivatable DNA processing enzymes Journal Article

In: Nucleic Acids Res, 2021, ISSN: 1362-4962.

Abstract | Links | BibTeX

Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization

Andrés Manuel Vera; Albert Galera-Prat; Michał Wojciechowski; Bartosz Różycki; Douglas V. Laurents; Mariano Carrión-Vázquez; Marek Cieplak; Philip Tinnefeld

Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization Journal Article

In: Structure, vol. 29, no. 6, pp. 587–597.e8, 2021.

Links | BibTeX

Andrés Manuel Vera; Philip Tinnefeld

Single-Molecule Approved Surface Passivation Journal Article

In: Structure, vol. 28, no. 12, pp. 1269–1270, 2020.

Links | BibTeX

Zhaowei Liu; Haipei Liu; Andrés M. Vera; Rafael C. Bernardi; Philip Tinnefeld; Michael A. Nash

High force catch bond mechanism of bacterial adhesion in the human gut Journal Article

In: Nature Communications, vol. 11, no. 1, 2020.

Links | BibTeX

Kevin Kramm; Tim Schröder; Jerome Gouge; Andrés Manuel Vera; Kapil Gupta; Florian B. Heiss; Tim Liedl; Christoph Engel; Imre Berger; Alessandro Vannini; Philip Tinnefeld; Dina Grohmann

DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability Journal Article

In: Nature Communications, vol. 11, no. 1, 2020.

Links | BibTeX

Björn Hellenkamp; Sonja Schmid; Olga Doroshenko; Oleg Opanasyuk; Ralf Kühnemuth; Soheila Rezaei Adariani; Benjamin Ambrose; Mikayel Aznauryan; Anders Barth; Victoria Birkedal; Mark E. Bowen; Hongtao Chen; Thorben Cordes; Tobias Eilert; Carel Fijen; Christian Gebhardt; Markus Götz; Giorgos Gouridis; Enrico Gratton; Taekjip Ha; Pengyu Hao; Christian A. Hanke; Andreas Hartmann; Jelle Hendrix; Lasse L. Hildebrandt; Verena Hirschfeld; Johannes Hohlbein; Boyang Hua; Christian G. Hübner; Eleni Kallis; Achillefs N. Kapanidis; Jae-Yeol Kim; Georg Krainer; Don C. Lamb; Nam Ki Lee; Edward A. Lemke; Brié Levesque; Marcia Levitus; James J. McCann; Nikolaus Naredi-Rainer; Daniel Nettels; Thuy Ngo; Ruoyi Qiu; Nicole C. Robb; Carlheinz Röcker; Hugo Sanabria; Michael Schlierf; Tim Schröder; Benjamin Schuler; Henning Seidel; Lisa Streit; Johann Thurn; Philip Tinnefeld; Swati Tyagi; Niels Vandenberk; Andrés Manuel Vera; Keith R. Weninger; Bettina Wünsch; Inna S. Yanez-Orozco; Jens Michaelis; Claus A. M. Seidel; Timothy D. Craggs; Thorsten Hugel

Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study Journal Article

In: Nature Methods, vol. 15, no. 9, pp. 669–676, 2018.

Links | BibTeX

  • A. M. Vera*, M. Carrión-Vázquez, Direct Identification of Protein–Protein Interactions by Single-Molecule Force Spectroscopy. Angewandte Chemie International Edition 55, 13970-13973 (2016).
  • A. M. Vera* et al., smFRET Detects Dual Binding Modes Modulated by Proline Isomerization in a Mega-Dalton Multi-Enzyme Complex. 2019.2012.2019.882373 (2019).

*corresponding author