Office | 089/2180-77547 (Frau Steger) |
Telephone | 089/2180-77537 |
Room | E1.003 |
Andres.Vera-Gomez”at”cup.lmu.de |
I did my PhD in the Cajal Institute (Madrid, Spain), where I used AFM-based Single-Molecule Force Spectroscopy to study the mechanical properties of proteins and protein complexes (1.). Afterward, I was granted with a Marie Curie Individual Fellowship and move to Germany and join the lab of Professor Tinnefeld, where I learnt to master Single-Molecule FRET techniques (2.) and made myself familiar with the versatility of DNA-nanotechnology (3.).
Nowadays, I am the leader of the Single-Molecule biophysics subgroup in the Tinnefeld Lab, where I focus my energy on understanding the regulation and dynamics of multi-enzymatic bacterial protein complexes (4.,5.). Besides, I have recently developed a new technology to generate light-activated DNA and RNA polymerases on demand, which can be used for biotechnological applications and we are certain will revolutionize the qPCR and Hot start PCR field.
Publications
Engineering an artificial catch bond using mechanical anisotropy Journal Article
In: Nature Communications, 2024.
Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions Journal Article
In: Nature Communications, 2024.
A simple and general approach to generate photoactivatable DNA processing enzymes Journal Article
In: Nucleic Acids Res, 2021, ISSN: 1362-4962.
Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization Journal Article
In: Structure, vol. 29, no. 6, pp. 587–597.e8, 2021.
Single-Molecule Approved Surface Passivation Journal Article
In: Structure, vol. 28, no. 12, pp. 1269–1270, 2020.
High force catch bond mechanism of bacterial adhesion in the human gut Journal Article
In: Nature Communications, vol. 11, no. 1, 2020.
DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability Journal Article
In: Nature Communications, vol. 11, no. 1, 2020.
Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study Journal Article
In: Nature Methods, vol. 15, no. 9, pp. 669–676, 2018.
- A. M. Vera*, M. Carrión-Vázquez, Direct Identification of Protein–Protein Interactions by Single-Molecule Force Spectroscopy. Angewandte Chemie International Edition 55, 13970-13973 (2016).
- A. M. Vera* et al., smFRET Detects Dual Binding Modes Modulated by Proline Isomerization in a Mega-Dalton Multi-Enzyme Complex. 2019.2012.2019.882373 (2019).
*corresponding author